Study case

We present here a dataset that will be used as study case to apply different approaches of multivariate analysis:

• data exploration
• multidimensional scaling
• differential analysis
• clustering (unsupervised classification)
• supervised classification

Reference: Den Boer ML et al. (2009). A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol. 2009 10:125-34. [doi: 10.1016/S1470-2045(08)70339-5], [PMID 19138562]. Data available at Gene Expression Omnibus, series [GSE13425]

Identification of signatures for subtypes of leukemia

Figure 1 from Den Boer et al. (2009).

Hierarchical clustering of genes and samples

Figure 2 from Den Boer et al. (2009).

Survival curves

Figure 3 from Den Boer et al. (2009).